Data sets

Metadata

Variable	Description/Code	Unit
Prepar	Preparation 1=SOL 2=ROCHE 3=BASF-30 4=BASF-60
Id	Subject #
Base1lvl	1st Baseline Level	µmol/L
Base2lvl	2nd Baseline Level	µmol/L
Wk6lvl	Week 6 Level	µmol/L
Wk8lvl	Week 8 Level	µmol/L
Wk10lvl	Week 10 Level	µmol/L
Wk12lvl	Week 12 Level	µmol/L

BLOOD

A case-control study of riskfactors (hormone levels in blood samples) for breast cancer. Individuals are matched on age and current postmenopausal homone use (PMH).

Each row contains unique ID, representing both cases (have breast cancer) and control (does not have breast cancer). The column matchid matches the controls with their respective cases. Cases have identical ID and matchid.

Note the different ways of coding missing values.

Useful for logistic regression to assess the association between testosterone and breast cancer, controlling for age and current PMH use. Either with testosterone as a continuous variable or as a categorical variabel in quartiles, with the first quartile as the reference group.

Dimensions: Rows: 510 Columns: 9

Metadata

Variable	Description	Unit
Id	ID
matchid	Matched ID
case	1 = case 0 = control
curpmh	Current PMH use 1 = yes 0 = no
ageblood	Age at blood draw	years
estradol	Estradiol	pg/mL
estrone	Estrone missing = 999	pg/mL
testost	Testosterone missing = 999	ng/dL
prolactn	Prolactin missing = 99.99	ng/L

BONEDEN

Data from a twin study on the relationship between bone density and cigarette consumption source². 41 pairs of middle-aged australian female twins with different smoking histories had their bone density measured at a hospital in Victoria, as well as other factors, details in metadata below.

Dimensions: Rows: 41 Columns: 25

Metadata

The data set is rather wide, and the columns are split up in this describtion.

Variable	Code	Unit
ID
Age	Age	years
zyg	Mono- or dizygotic twins 1 = mz 2 = dz

The following variables are dublicated, in the form of

xx1 for the lighter smoking twin and

xx2 for the heavier smoking twin

Variable	Code	unit
ht	Height	cm
wt	Weight	kg
tea	Tea	cups/week
cof	Coffee	cups/week
alc	Alcohol	drinks/week
cur	Current Smoking	(cigarettes/day)
men	Menopause Status 0: Premenopausal 1: Postmenopausal 2: unknown or hysterectomy
pyr	Pack-years smoking	year
ls	Lumbar spine	g/cm²
fn	Femoral neck	g/cm²
fs	Femoral shaft	g/cm²

Pack-years are defined as how many years the woman have smoked a pack of cigarettes pr day, normally ca. 20 cigarettes pr pack.

Lumbar spine: L1-L5.

Femoral neck: Collum femoris

Femoral shaft: Corpus femoris

BOTOX

69 patients with piriformis syndrome participated in a randomized double-blind clinical trial.

Piriformis syndrom is a condition involving malfunction of the piriformis muscle - a deep buttock muscle, which often causes buttock and lumbar pain with sciatica.

Patients were injected with one of three substances directly in the piriformis muscle:

a combination of triamcinolone and lidocaine (TL)
a placebo
Botox

The randomization was set up with approximately ½ assigned to group 1, 1/6 to group 2 and 1/3 to group 3.

Patients were asked to return 2 weeks (0.5), and monthly post injection. At each visit patients rated their percentage of improvement of pain comparied to baseline, on a visual analog scale, with a range of -100 to 100%, negative numbers indicating worsening. One patient had the condition in both legs leading to 70 observations in the dataset.

Dimensions: Rows: 70 Columns: 24

Metadata

Variable	Code	unit
ID
group	1 = TL 2 = Placebo 3 = Botox
pain0	pain score month 0	%
pain05	pain score month 0.5	%
pain1	pain score month 1	%
pain2	pain score month 2	%
pain3	pain score month 3	%
pain4	pain score month 4	%
pain5	pain score month 5	%
pain6	pain score month 6	%
pain7	pain score month 7	%
pain8	pain score month 8	%
pain9	pain score month 9	%
pain10	pain score month 10	%
pain11	pain score month 11	%
pain12	pain score month 12	%
pain13	pain score month 13	%
pain14	pain score month 14	%
pain15	pain score month 15	%
pain16	pain score month 16	%
pain17	pain score month 17	%

For all pain scores 999 indicates missing value.

BREAST

A dataset describing 1200 women in the NHS. In 1990 it was confirmed that they were postmenopausal and free of any cancer. The selection was done so that 200 of the women were using postmenopausal hormones (PMH) in 1990, and 1000 had never used PMH. The objective was to identify a possible relation between incidence of breast cancer between 1990 to 2000 with PMH use in 1990.

The objective was to relate breast cancer incidence from 1990 to 2000 with PMH use in 1990. Data on PMH use are found in three variables, pmh registers PMH use in 1990, where dur3 and dur4 registers length of use of two different PMH. In the variable foluptm the time between the first questionnaire (in 1990), and a follow up date is recorded in months. If a control that follow up date was the date of the last questionnaire in 2000, if a case, the date of diagnosis of breast cancer. Other cancer risk factors are recorded.

Dimensions: Rows: 1200 Columns: 18

Metadata

variable	Description	unit
Id	ID
case	case 1 = case 0 = control
age	age	years
agemenar	age at menarche	years
agemenop	age at menopause	years
afb	age at first birth 98=nullip	years
parity	parity
bbd	Benign Breast disease 1 = yes 0 = no
famhx	family history breast cancer 1 = yes 0 = no
bmi	BMI	kg/m²
hgt	Height	inches
alcohol	Alcohol use	g/day
pmh	PMH status 2 = never user 3 = current user
dur3	Duration of Estrogen use (months)	months
dur4	Duration of Estrogen + progesterone use (months)	months
csmk	Current Smoker 1 = yes 0 = no
psmk	Past smoker 1 = yes 0 = no
foluptm	Months of follow up Note: Some subjects provided no follow up after the 1990 questionnaire: foluptm=0 for these people	months

CORNEAL

Data from a randomized trial of two different active drugs of the fluoroquinolone-group, M and G along with a placebo, P. 93 subjects were placed in one of three groups:

Group	Eye 1	Eye 2
A	G	P
B	M	P
C	G	M

Each subject was asked to administer the two assigned preparations four times per day for 10 days. The response was measured at baseline (without treatment), on visit 1, and again at visit 2 after 7 days, and at visit 3, on day 14. Note that at day 14, the subjects had stopped administering the preparations. The response was meased as corneal sensitivity in five regions of the eyes, central, superior, inferior, temporal and nasal. Sensititivy was measured in mm, with a range for 40-60 mm. High values indicate greater, normal, sensitivity, low values lower, abnormal, sensitivity.

Dimensions: Rows: 186 Columns: 17

Metadata

Variable	Variable label	unit
id	ID
tr	Treatment 1 = M 2 = G 3 = P
c1	Central visit 1	mm
s1	Superior visit 1	mm
i1	Inferior Visit 1	mm
t1	Temporal visit 1	mm
n1	Nasal Visit 1	mm
c2	Central Visit 2(day 7)	mm
s2	Superior Visit 2	mm
i2	Inferior Visit 2	mm
t2	Temporal Visit 2	mm
n2	Nasal Visit 2	mm
c3	Central Visit 3(day 14)	mm
s3	Superior Visit 3	mm
i3	Inferior Visit 3	mm
t3	Temporal Visit 3	mm
n3	Nasal Visit 3	mm

99: Missing values

DIABETES

A study on whether maintaining diabetes control in type I diabetes affects growth and development in childhood. 94 boys aged 9-15 where examined approx. every 3 months, leading to 910 visits. At each visit the degree of diabetes control where assessed by measuring HgbA1c (glycosylated hemoglobin). The exact dates of the visits are registered in the mon, day and yr_a1c variables, the age, height and weight where registered as well ad the HgbA1c measurement.

The HgbA1c measurement is the percentage of hemoglobin that is glycosylated. The normal range is between 4.0 and 5.6%, with values larger than 6.5% being indicative of diabetes. The normal range does not appear to change by pubertal stage.

Dimensions: Rows: 910 Columns: 8

Metadata

Variable	Code	unit
ID
mon_a1c	Month
day_a1c	Day A1c
yr_a1c	Yr
age_yrs	Age in years	year
gly_a1c	Hemoglobin A1c	%
ht_cm	Height missing=999.9	cm
wt_kg	Weight	kg

EAR

Data on 214 children with acute otitis media in one or both ears. They were randomly assigned 14 days of antibiotic treatment with either CEF (cefaclor) or AMO (amoxicillin). Status of their ear infection at a follow up visit after 14 days were recorded.

Dimensions: Rows: 278 Columns: 5

Additional reference

Metadata

Variable	Description
Id	ID
Clear	Clearance by 14 days 1 = yes 0 = no
Antibo	Antibiotic 1 = CEF 2 = AMO
Age	Age 1 = <2 yrs 2 = 2-5 yrs 3 = 6+ yrs
Ear	Ear 1 = 1st ear 2 = 2nd ear

EFF

Data from a litterature search on the efficacy (that is - is it working?) of a number of aminoglycosides for the treatment of infectious diseases.

Note that this dataset is basically the same as the dataset NEPHRO, where the nephrotoxicity of the preparations described in the same papers is reported.

We get the sample size of patients in different studies, and the number of patients that were cured for their infection. Which antibiotic is best?

Dimensions: Rows: 64 Columns: 6

Metadata

Variable	Description/Code
Name	Study name
Id	Study Number
Endpnt	Endpoint 1=efficacy
Antibio	Antibiotic
	1 = Amikacin 2 = Gentamicin 3 = Netilmicin 4 = Sisomycin 5 = Tobramycin
Samp_sz	Sample Size
Cured	Number Cured

ENDOCRIN

Data for comparison of measurements of four hormones in five subjects. Measurements were done twice on blood samples from each subject. Are the measurements reproducable?

Dimensions: Rows: 10 Columns: 6

Metadata

Variable	LABEL	unit
Subject	SUBJECT #
Replicat	REPLICATE #
Estrone	ESTRONE	pg/mL
Estradol	ESTRADIOL	pg/ml
Androste	ANDROSTENEDIONE	ng/dL
Testost	TESTOSTERONE	ng/dL

ESTRADL

Data on 211 women. Measurement of estradiol, ethnicity, number of children, BMI and Waist/hip ratio.

Dimensions: Rows: 211 Columns: 10

Metadata

Variable	Code	unit
Id	Identification number
Estradl	Estradiol	pg/ml
Ethnic	Ethnicity 0 = African-American 1 = Caucasian
Entage	Age	year
Numchild	Parity, number of children 9=missing
Agefbo	Age at 1st birth (= 0 if numchild = 0) 99 = missing	year
Anykids	Any children 1 = yes 0 = no 9 = missing
Agemenar	Age at menarche 99=missing	years
BMI	Body Mass Index	kg/^m^
WHR	waist-hip ratio

CAVE: Note the coding of Agefbo

ESTROGEN

The influence on different doses of estrogen on systolic and diastolic blood pressure is investigated. 31 subjects are placed into 1 of three study types, and recives treatment two times for four weeks, with a two week washout period between.

Are there any significant differences between the different treatments - or carry over effects on blood pressure in the different groups.

Dimensions: Rows: 62 Columns: 22

Metadata

Variable	LABEL	unit
Id	ID
std_typ	STUDY TYPE 1 = 0.625MG VS PLACEBO 2 = 1.25MG VS PLACEBO 3 = 1.25MG VS 0.625MG
period	PERIOD
trtgrp	TREATMENT 1 = PLACEBO 2 = 0.625MG 3 = 1.25MG
sysd1r1	SYSTOLIC BP DAY 1 READING 1	mmHg
diasd1r1	DIASTOLIC BP DAY 1 READING 1	mmHg
sysd1r2	SYSTOLIC BP DAY 1 READING 2	mmHg
diasd1r2	DIASTOLIC BP DAY 1 READING 2	mmHg
sysd1r3	SYSTOLIC BP DAY 1 READING 3	mmHg
diasd1r3	DIASTOLIC BP DAY 1 READING 3	mmHg
sysd2r1	SYSTOLIC BP DAY 2 READING 1	mmHg
diasd2r1	DIASTOLIC BP DAY 2 READING 1	mmHg
sysd2r2	SYSTOLIC BP DAY 2 READING 2	mmHg
diasd2r2	DIASTOLIC BP DAY 2 READING 2	mmHg
sysd2r3	SYSTOLIC BP DAY 2 READING 3	mmHg
diasd2r3	DIASTOLIC BP DAY 2 READING 3	mmHg
sysd3r1	SYSTOLIC BP DAY 3 READING 1	mmHg
diasd3r1	DIASTOLIC BP DAY 3 READING 1	mmHg
sysd3r2	SYSTOLIC BP DAY 3 READING 2	mmHg
diasd3r2	DIASTOLIC BP DAY 3 READING 2	mmHg
sysd3r3	SYSTOLIC BP DAY 3 READING 3	mmHg
diasd3r3	DIASTOLIC BP DAY 3 READING 3	mmHg

999: Missing bloodpressure data.

FEV

Data on 654 children seen in the Childhood Respiratory Disease Study⁶ in East Boston Massachusetts in 1980. Forced Expiratory Volumne (FEF), an index of pulmonary function was measured, along with, age, height, sex and smoking status.

FEV is the volume of air (in liters) that can be expelled from the lungs in one second.

Usefull for demonstrating linear regressions, also multiple linear regression with categorical interactions, and change in FEV as a function of height and sex.

Dimensions: Rows: 654 Columns: 6

Metadata

Variable	Description	Unit
Id	ID number
Age	Age	years
FEV	FEV	l
Hgt	Height	in
Sex	Sex 0 = female 1 = male
Smoke	Smoking Status 0 = non-current smoker 1 = current smoker

FIELD

Data from a study of the ocular disease Retinitis pigmentosoa (RP). The condition can result in substantial loss of vision, in some cases complete blindness. It has been discovered that this disease is linked to two genes. Mutations in the rhodosin gene RHO account for many cases that are predominantly inherited, whereas mutations in the RPGR gene account for many sex-linked cases; only males can have the RPGR mutation. The study measures the visual field of approx. 100 patients in each group (RHO and RPGR). The field of vision is measured in °².

Are there differences in the baseline level of visual field between the two groups? Does the rate of decline differ between the two groups?

Dimensions: Rows: 1326 Columns: 8

Metadata

Variable	Description	unit
id	ID
group	group 1 = RHO 2 = RPGR
age	age at visit	years
gender	gender 1 = m 2 = f
dtvisit	date of visit (month/day/year)
folowup	time from 1st visit	years
totfldod	total field area right eye (OD)	°²
totfldos	total field area left eye (OS)	°²

Note: all RPGR individuals have to be male

HEART

A dataset showing the prevalence of different heart conditions, in different populations, and of different symptoms.

Dimensions: Rows: 7 Columns: 9

Metadata

Variable	code
Diagnosis	Y1 = normal Y2 = atrial septal defect without pulmonary stenosis or pulmonary hypertension Y3 = ventricular septal defect with valvular pulmonary stenosis Y4 = isolated pulmonary hypertension Y5 = transposed great vessels Y6 = ventricular septal defect without pulmonary hypertension Y7 = ventricular septal defect with pulmonary hypertension
Prevalence	Prevalence
X1	age 1-20 years old
X2	age>20 years old
X3	mild cyanosis
X4	easy fatigue
X5	chest pain
X6	repeated respiratory infections
X7	EKG axis more than 110

HORMONE

Data on the influence of four hormones, compared with a saline solution on the pancreatic and biliary secretions in laying hens. White leghorn hens, aged 14-29 weeks, were fitted with cannulas for collection of pancreatic and biliary secretions, and a jugular cannula for infusion of the hormones. One trial pr day was performed, until the jugular cannula stopped working - therefore there are a different number of observations pr. hen.

Each trial

Dimensions: Rows: 398 Columns: 11

Metadata

Variable	Description/Code	unit
ID	ID
Bilsecpr	Biliary secretion-pre	µl/min
Bilphpr	Biliary pH-pre	pH
Pansecpr	Pancreatic secretion-pre	µl/min
Panphpr	Pancreatic pH-pre	pH
Dose	Dose	APP: ng/mL plasma CKK, VIP, SEC: µg/kg/h
Bilsecpt	Biliary secretion-post	µl/min
Bilphpt	Biliary pH-post	pH
Pansecpt	Pancreatic secretion-post	µl/min
Panphpt	Pancreatic pH-post	pH
Hormone	Hormone 1 = SAL 2 = APP 3 = CCK 4=SEC 5=VIP

A value of 0 for pH indicate missing values.

SAL: Saline
APP: Avian pancreatic polypeptide
CCK: Cholecystokinin
SEC: Secretine
VIP: Vasoactive intestinal peptide

HOSPITAL

Dimensions: Rows: 25 Columns: 9

Metadata

Variable	Label	unit
Id	id no.
Dur_stay	Duration of hospital stay
Age	Age
Sex	Sex 1 = male 2 = female
Temp	First temperature following admission
WBC	First WBC(x1000) following admission
Antibio	Received antibiotic 1 = yes 2 = no
Bact_cul	Received bacterial culture 1 = yes 2 = no
Service	Service 1 = med 2 = surg.

Fra studie af antibiotikabrug på et hospital i Pennsylvania. Baseret på journaler fra patienter der er udskrevet. WBC er “White Bloodcell Count”.

Det kan have klinisk interesse om længden af indlæggelse er afhængig af om patienterne modtager antibiotika behandling.

Yderligere reference:

Townsend, T.R., Shapiro, M., Rosner, B. & Kass, E.H. (1979) Journal of Infectious Diseases, 139(6) 688-697.

INFANTBP

Dimensions: Rows: 100 Columns: 18

Salt Taste Variables

Metadata

Variable	Description	unit
ID
Mn_sbp	Mean SBP 99.99=missing
Mn_dbp	Mean DBP 99.99=missing
MSB1slt	MSB-trial 1* water
MSB2slt	MSB-trial 2 water
MSB3slt	MSB-trial 3 0.1 molar salt + water
MSB4slt	MSB-trial 4 0.1 molar salt + water
MSB5slt	MSB-trial 5 water
MSB6slt	MSB-trial 6 water
MSB7slt	MSB-trial 7 0.3 molar salt + water
MSB8slt	MSB-trial 8 0.3 molar salt + water
MSB9slt	MSB-trial 9 water
MSB10slt	MSB-trial 10 water

Sugar Taste Variables

Variable	Description
MSB1sug	MSB-trial 1 non-nutritive sucking
MSB2sug	MSB-trial 2 water
MSB3sug	MSB-trial 3 5% sucrose + water
MSB4sug	MSB-trial 4 15% sucrose + water
MSB5sug	MSB-trial 5 non-nutritive sucking

for MSB data 999.99 is a missing value; 0 indicates the baby did not suck.

LEAD

Dimensions: Rows: 124 Columns: 40

Metadata

VARIABLE	DESCRIPTION
id	IDENTIFICATION NUMBER
area	AREA - RESIDENCE ON AUG’72 1 = 0-1 MILES FROM SMELTER 2 = 1-2.5 MILES 3 = 2.5-4.1 MILES
ageyrs	AGE in years
sex	SEX 1 = MALE 2 = FEMALE

IQ TEST RESULTS

VARIABLE	DESCRIPTION
iqv_inf	INF - INFORMATION SUBTEST IN WISC AND WPPSI
iqv_comp	COMP - COMPREHENSION SUBTEST IN WISC AND WPPSI
iqv_ar	AR - ARITHMETIC SUBTEST IN WISC AND WPPSI
iqv_ds	DS - DIGIT SPAN SUBTEST(WISC) AND SENTENCE COMPLETION(WPPSI)
iqv_raw	V/RAW - RAW SCORE/VERBAL IQ
iqp_pc	PC - PICTURE COMPLETION SUBTEST IN WISC AND WPPSI
iqp_bd	BD - BLOCK DESIGN SUBTEST IN WISC AND WPPSI
iqp_oa	OA - OBJECT ASSEMBLY SUBTEST(WISC), ANIMAL HOUSE SUBTEST(WPPSI)
iqp_cod	COD - CODING SUBTEST(WISC), GEOMETRIC DESIGN SUBTEST(WPPSI)
iqp_raw	P/RAW - RAW SCORE/PERFORMANCE IQ (TOTAL OF SCORES PC, BD, OA, & COD)
hh_index	HH/INDEX - HOLLINGSHEAD INDEX OF SOCIAL STATUS
iqv	IQV - VERBAL IQ
iqp	IQP - PERFORMANCE IQ
iqf	IQF - FULL SCALE IQ (NOT SUM OR AVERAGE OF IQV D IQP)
iq_type	TYPE OF IQ TEST 1 = WISC 2 = WPPSI (WISC USUALLY GIVEN TO CHILDREN GE 5 YRS 1 MONTH OF AGE WPPSI USUALLY GIVEN TO CHILDREN LE 5YRS OF AGE)
lead_grp	GROUP - BLOOD LEAD LEVEL GROUP
	1=BLOOD LEAD LEVELS BELOW 40 MICROGRAMS/100ML IN
	BOTH 1972 & 1973 (control group)
	2=BLOOD LEAD LEVELS GREATER THAN OR EQUAL TO
	40 MICROGRAMS/100ML
	IN BOTH 72 & 73 OR A LEVEL GREATER THAN OR
	EQUAL TO 40
	IN 73 ALONE (3 CASES ONLY) (currently exposed
	Group)
	3=BLOOD LEAD LEVELS GREATER THAN OR EQUAL TO
	40 MICROGRAMS/100ML
	IN 72 AND LESS THAN 40 IN 73
	(previously exposed group)
Group	1=control group; 2=exposed group
ld72	LD72 - BLOOD LEAD VALUES (MICROGRAMS/100ML) IN72
	MISSING=99
ld73	LD73 - BLOOD LEAD VALUES (MICROGRAMS/100ML) IN 73
fst2yrs	FST2YRS - DID CHILD LIVE FOR 1ST 2 YRS WITHIN
	1 MILE OF SMELTER 1=YES 2=NO
totyrs	TOTYRS - TOTAL NUMBER OF YEARS SPENT WITHIN
	4.1 MILES OF SMELTER

SYMPTOM DATA (AS REPORTED BY PARENTS)

VARIABLE	DESCRIPTION
pica	PICA 1 = YES 2 = NO
colic	COLIC 1 = YES 2 = NO
clumsi	CLUMSINESS 1 = YES 2 = NO
irrit	IRRITABILITY 1 = YES 2 = NO
convul	CONVULSIONS 1 = YES 2 = NO

CONTAIN NEUROLOGICAL TEST DATA

VARIABLE	DESCRIPTION
_2plat_r	# OF TAPS FOR RIGHT HAND IN THE 2-PLATE TAPPING
	TEST (#TAPS IN ONE 10 SECOND TRIAL)
	MISSING=99
_2plat_l	# OF TAPS FOR LEFT HAND IN THE 2-PLATE TAPPING TEST
	(#TAPS IN ONE 10 SECOND TRIAL)
	MISSING=99
visrea_r	VISUAL REACTION TIME RIGHT HAND (MILLISECONDS)
	MISSING=99
visrea_l	VISUAL REATION TIME LEFT HAND (MILLISECONDS)
	MISSING=99
audrea_r	AUDITORY REACTION TIME RIGHT HAND (MILLISECONDS)
	MISSING=99
audrea_l	AUDITORY REACTION TIME LEFT HAND (MILLISECONDS)
	MISSING=99
fwt_r	FINGER-WRIST TAPPING TEST RIGHT HAND
	(# TAPS IN ONE 10 SECOND TRIAL)
	MISSING=99
fwt_l	FINGER-WRIST TAPPING TEST LEFT HAND
	(#TAPS IN ONE 10 SECOND TRIAL)
	MISSING=99
hyperact	WWPS - WERRY-WEISS-PETERS SCALE FOR HYPERACTIVITY
	0=NO ACTIVITY . . . . 4=SEVERLY HYPERACTIVE
	(AS REPORTED BY PARENTS) MISSING=99
maxfwt	Finger-wrist tapping test in dominant hand(max of fwt_r,fwt_l)

MICE

Dimensions: Rows: 240 Columns: 6

Metadata

Variable	Description	unit
Id	ID
Group	1 = RP 2 = NORMAL
Trtgrp	TREATMENT GROUP A = LIGHT B = DIM C = DARK
Age	AGE	days
B_amp	B AMP
A_amp	A AMP

9999 = missing.

NEPHRO

Data from a litterature study⁵ on nephrotoxicity of of several different aminoclycosides.

Note that this dataset is closely related to the datasets EFF and OTO, where EFF reports efficacy of the preparations, and OTO reports a combination of efficacy and side effects.

We get the sample size of patients in different studies, and the number of patients that experienced nephrotoxicity. Which antibiotic is best?

Dimensions: Rows: 72 Columns: 6

Metadata

Variable	Description/Code
name	Study name
id	Study number
Endpnt	Endpoint 2=nephrotoxicity
Antibio	Antibiotic 1=Amikacin 2=Gentamicin 3=Netilmicin 4=Sisomycin 5=Tobramycin
Samp_sz	Sample size
Side_eff	Number with side effects

NIFED

Dimensions: Rows: 34 Columns: 10

Metadata

Variable	Description	Code
Id	ID
trtgrp	Treatment group	N=nifedipine/P=placebo
bashrtrt	Baseline heart rate*	beats/min
lv1hrtrt	Level 1 heart rate+	beats/min
lv2hrtrt	Level 2 heart rate	beats/min
lv3hrtrt	Level 3 heart rate	beats/min
bassys	Baseline systolic bp*	mm Hg
lv1sys	Level 1 systolic bp	mm Hg
lv2sys	Level 2 systolic bp	mm Hg
lv3sys	Level 3 systolic bp	mm Hg

Immediately prior to randomization.
Highest heart rate and systolic blood pressure at baseline and each level of therapy respectively.

Values of 999 indicates that either

the patient withdrew from the study prior to entering this level of therapy
the patient achieved pain relief prior to reaching this level or therapy,
the patient encountered this level of therapy, but this particular piece of data was missing.

OTO

Data from a litterature study⁵ on nephro- and ototoxicity and efficacy of of several different aminoclycosides.

Note that this dataset is closely related to the datasets EFF and NEPHRO, where EFF reports efficacy of the preparations, and NEPHRO reports on nephrotoxicity.

We get the sample size of patients in different studies, and the number of patients that experienced sideeffects. Which antibiotic is best?

Dimensions: Rows: 50 Columns: 6

Metadata

Variable	Description/Code
Name	Study Name
Id	Study Number
Endpnt	Endpoint 1 = efficacy 2 = nephrotoxicity 3 = ototoxicity
Antibio	Antibiotic 1 = Amikacin 2 = Gentamicin 3 = Netilmicin 4 = Sisomycin 5 = Tobramycin
Samp_sz	Sample Size
Side_eff	Number with side effect

PIRIFORM

Dimensions: Rows: 631 Columns: 5

Metadata

Variable	Code
ID
piriform	Piriformis Syndrome 1 = Negative 2 = Positive
sex	Sex 1 = Male 2 = Female
	Age
maxchg	Max change between tibia and peroneal

SEXRAT

Dimensions: Rows: 60 Columns: 8

Metadata

Variable	code
nm_chld+	Number of children
sx_1	Sex of 1st born
sx_2	Sex of 2nd born
sx_3	Sex of 3rd born
sx_4	Sex of 4th born
sx_5	Sex of 5th born
sexchldn*	Sex of all children
num_fam**	Number of families

For families with 5+ children, the sex of the first 5 children are listed. The number of children is given as 5 for such families.
The sex of successive births is given. Thus, MMMF means that the first three children were males and the fourth child was a female. There were 484 such families.

** Number of families with specific gender contribution of children

SMOKE

Dimensions: Rows: 234 Columns: 8

Metadata

Variable	Code	unit
ID	ID number
Age	age
Gender	Gender 1 = male 2 = female
Cig_day	Cigarettes/day
CO	Carbon monoxide (CO) (X 10)
Min_last	Minutes elapsed since last cigarette
LogCOadj	Log CO Adj * (X 1000)
Day_abs	Days abstinent Those abstinent less than 1 day were given a value of zero.

999 and 9999 = missing values

This variable represents adjusted carbon monoxide (CO) values. CO values were adjusted for minutes elapsed since last cigarette smoked using the formula Log 10 CO (Adjusted) = Log 10 CO - (-0.000638) X (Min - 80), where Min is the number of minutes elapsed since the last cigarette smoked.

SWISS

Dimensions: Rows: 300 Columns: 10

Metadata

Variable	Codes	unit
ID	ID
age	age	years
group	Group 1 = High NAPAP 2 = Low NAPAP 3 = control
creat_68	Serum Creatinine 1968	(mg/dL)
creat_69	Serum Creatinine 1969	(mg/dL)
creat_70	Serum Creatinine 1970	(mg/dL)
creat_71	Serum Creatinine 1971	(mg/dL)
creat_72	Serum Creatinine 1972	(mg/dL)
creat_75	Serum Creatinine 1975	(mg/dL)
creat_78	Serum Creatinine 1978	(mg/dL)

For all creat_xx: 9.99 indicates missing data, i.e. NA-values.

TEAR

Dimensions: Rows: 14 Columns: 61

Metadata

Variable	Code
ID
od3bas1	OD 3sec baseline 1
od3bas2	OD 3 sec baseline 2
od3im1	OD 3 sec immediately post 1
od3im2	OD 3 sec immediately post 2
od3pst51	OD 3 sec 5min post 1
od3pst52	OD 3 sec 5min post 2
od3pt101	OD 3 sec 10min post 1
od3pt102	OD 3 sec 10min post 2
od3pt151	OD 3 sec 15min post 1
od3pt152	OD 3 sec 15min post 2
os3bas1	OS 3sec baseline 1
os3bas2	OS 3 sec baseline 2
os3im1	OS 3 sec immediately post 1
os3im2	OS 3 sec immediately post 2
os3pst51	OS 3 sec 5min post 1
os3pst52	OS 3 sec 5min post 2
os3pt101	OS 3 sec 10min post 1
os3pt102	OS 3 sec 10min post 2
os3pt151	OS 3 sec 15min post 1
os3pt152	OS 3 sec 15min post 2
od6bas1	OD 6 sec baseline 1
od6bas2	OD 6 sec baseline 2
od6im1	OD 6 sec immediately post 1
od6im2	OD 6 sec immediately post 2
od6pst51	OD 6 sec 5min post 1
od6pst52	OD 6 sec 5min post 2
od6pt101	OD 6 sec 10min post 1
od6pt102	OD 6 sec 10min post 2
od6pt151	OD 6 sec 15min post 1
od6pt152	OD 6 sec 15min post 2
os6bas1	OS 6 sec baseline 1
os6bas2	OS 6 sec baseline 2
os6im1	OS 6 sec immediately post 1
os6im2	OS 6 sec immediately post 2
os6pst51	OS 6 sec 5min post 1
os6pst52	OS 6 sec 5min post 2
os6pt101	OS 6 sec 10min post 1
os6pt102	OS 6 sec 10min post 2
os6pt151	OS 6 sec 15min post 1
os6pt152	OS 6 sec 15min post 2
od10bas1	OD 10 sec baseline 1
od10bas2	OD 10 sec baseline 2
od10im1	OD 10 sec immediately post 1
od10im2	OD 10 sec immediately post 2
od10ps51	OD 10 sec 5min post 1
od10ps52	OD 10 sec 5min post 2
od10p101	OD 10 sec 10min post 1
od10p102	OD 10 sec 10min post 2
od10p151	OD 10 sec 15min post 1
od10p152	OD 10 sec 15min post 2
os10bas1	OS 10 sec baseline 1
os10bas2	OS 10 sec baseline 2
os10im1	OS 10 sec immediately post 1
os10im2	OS 10 sec immediately post 2
os10ps51	OS 10 sec 5min post 1
os10ps52	OS 10 sec 5min post 2
os10p101	OS 10 sec 10min post 1
os10p102	OS 10 sec 10min post 2
os10p151	OS 10 sec 15min post 1
os10p152	OS 10 sec 15min post 2

TEMPERAT

Dimensions: Rows: 630 Columns: 6

Metadata

Variable	LABEL	unit
Date	DATE (MDY)
Out_temp	OUTSIDE TEMERATURE	°F
Room	ROOM LOCATION
In_temp	INSIDE TEMPERATURE	°F
Cor_fac	CORRECTION FACTOR ADDED 1 = YES 0 = NO)
Typ_wea	TYPE OF WEATHER 1 = SUNNY 2 = PARTLY CLOUDY 3 = CLOUDY 4 = RAINY 5 = FOGGY 9 = MISSING

TENNIS1

Dimensions: Rows: 444 Columns: 12

Metadata

VARIABLE	VARIABLE NAME	unit
Id	ID
Age	AGE 99=MISSING
Sex	SEX
	1 = MALE
	2 = FEMALE
Num_epis	NUMBER OF EPISODES OF TENNIS ELBOW 9=MISSING
Typ_last	TYPE OF RACQUET USED DURING LAST EPISODE
	1 = CONVENTIONAL SIZE
	2 = MID-SIZE
	3 = OVER-SIZE
	9 = MISSING
Wgt_last	WEIGHT OF RACQUET USED DURING LAST EPISODE
	1=HEAVY
	2=MEDIUM
	3=LIGHT
	4=DON’T KNOW
	9=MISSING
Mat_last	MATERIAL OF RACQUET USED DURING LAST EPISODE
	1=WOOD
	2=ALUMINUM
	3=FIBERGLASS AND COMPOSITE
	4=GRAPHITE
	5=STEEL
	6=COMPOSITE
	7=OTHER
	9=MISSING
Str_last	STRING TYPE OF RACQUET USED DURING LAST EPISODE
	1=NYLON
	2=GUT
	3=DON’T KNOW
	9=MISSING
Typ_curr	TYPE OF RACQUET USED CURRENTLY
	1 = CONVENTIONAL SIZE
	2 = MID-SIZE
	3 = OVER-SIZE
	9 = MISSING
Wgt_curr	WEIGHT OF RACQUET USED CURRENTLY
	1 = HEAVY
	2 = MEDIUM
	3 = LIGHT
	4 = DON’T KNOW
	9 = MISSING
Mat_curr	MATERIAL OF RACQUET USED CURRENTLY
	1 = WOOD
	2 = ALUMINUM
	3 = FIBERGLASS AND COMPOSITE
	4 = GRAPHITE
	5 = STEEL
	6 = COMPOSITE
	7 = OTHER
	9 = MISSING
Str_curr	STRING TYPE OF RACQUET USED CURRENTLY
	1 = NYLON
	2 = GUT
	3 = DON’T KNOW
	9 = MISSING

TENNIS2

Dimensions: Rows: 88 Columns: 16

Metadata

VARIABLE	PERIOD*	VARIABLE NAME
id		ID
age		AGE
sex		SEX
		1 = MALE
		2 = FEMALE
		9 = MISSING
drg_ord		DRUG ORDER
		1 = MOTRIN-PLACEBO
		2 = PLACEBO-MOTRIN
painmx_2	2	DURING STUDY PERIOD, PAIN DURING MAXIMUM ACTIVITY VS
		BAESLINE
		1 = WORST
		2 = UNCHANGED
		3 = SLIGHTLY IMPROVED (25%)
		4 = MODERATELY IMPROVED (50%)
		5 = MOSTLY IMPROVED (75%)
		6 = COMPLETELY IMPROVED
		9 = MISSING
pain12_2	2	WITHIN 12 HOURS FOLLOWING MAXIMAL ACTIVITY, COMPARED TO
		SAME PERIOD AT BASELINE (SAME CODE AS painmx_2)
painav_2	2	DURING THE AVERAGE DAY OF STUDY PERIOD PAIN VS. BASELINE
		(SAME CODE AS painmx_2)
painov_2	2	OVERALL IMPRESSION OF DRUG EFFICACY VS. BASELINE (SAME CODE AS painmx_2)
painmx_3	3	DURING STUDY PERIOD, PAIN DURING MAXIMUM ACTIVITY VS
		BASELINE (SAME CODE AS painmx_2)
pain12_3	3	WITHIN 12 HOURS FOLLOWING MAXIMAL ACTIVITY, COMPARED TO
		SAME PERIOD AT BASELINE (SAME CODE AS painmx_2)
painav_3	3	DURING THE AVERAGE DAY OF STUDY PERIOD PAIN VS BASELINE
		(SAME CODE AS painmx_2)
painov_3	3	OVERALL IMPRESSION OF DRUG EFFICACY VS BASELINE
		(SAME CODE AS painmx_2)
painmx_4	4	DURING STUDY PERIOD, PAIN DURING MAXIMUM ACTIVITY VS
		BASELINE (SAME CODE AS painmx_2)
pain12_4	4	WITHIN 12 HOURS FOLLOWING MAXIMAL ACTIVITY, COMPARED TO
		SAME PERIOD AT BASELINE (SAME CODE AS painmx_2)
painav_4	4	DURING THE AVERAGE DAY OF STUDY PERIOD PAIN VS BASELINE
		(SAME CODE AS painmx_2)
painov_4	4	OVERALL IMPRESSION OF DRUG EFFICACY VS BASELINE
		(SAME CODE AS painmx_2)

PERIOD 2 = PAIN SCORES AFTER THE FIRST ACTIVE DRUG PERIOD COMPARED WITH BASELINE

PERIOD 3 = PAIN SCORES AFTER THE WASHOUT PERIOD COMPARED WITH BASELINE

PERIOD 4 = PAIN SCORES AFTER THE SECOND ACTIVE DRUG PERIOD COMPARED WITH BASELINE

VALID

Dimensions: Rows: 173 Columns: 9

Metadata

Variable	Description	unit
Id	ID number
sfat_dr	Saturated fat-DR
sfat_ffq	Saturated fat-FFQ
tfat_dr	Total fat-DR
tfat_ffq	Total fat-FFQ
alco_dr	Alcohol consumption-DR
alco_ffq	Alcohol consumption-FFQ
cal_dr	Total calories-DR
cal_ffq	Total calories-FFQ

spermatozoa

Data from a 7 year longitudinal study started in spring 1975 in Edinburgh. Two classes at an elementary school participated and informed consent were collected from 40 of the 42 boys in the classes. Every 3 months a 24 hour urine sample were collected from each boy. These samples were analyzed for the precense of spermatozoa. In the variable observations are registered the result of each urine sample.

The purpose of the study was to determine age of spermache.

The format of observations is unusual and suitable for cleaning exercises.

Det kan godt være vi lige skal kigge på:For further details about the study see Nielsen et al. (1986a, 1986b). mere præcist: Nielsen, C. T., Skakkebxk, N. E., Darling, J. A. B., Hunter, W. M., Richardson, D. W., Jorgensen, M., and Keiding, N. (1986a). Longitudinal study of testosterone and luteinizing hormone (LH) in relation to spermarche, pubic hair, height and sitting height in normal boys. Acta Endocrinologica 113, Supplementum 279, 98-106.

Nielsen, C. T., Skakkebxk, N. E., Richardson, D. W., Darling, J. A. B., Hunter, W. M., J0rgensen, M., Nielsen, A., Ingerslev, O., Keiding, N., and Muller, J. (1986b). Onset of the release of spermatozoa (spermarche) in boys in relation to age, testicular growth, pubic hair and height. Journal of Clinical Endocrinology and Metabolism 62, 532–535.

Dimensions: Rows: 40 Columns: 5

Også Rosner…

source⁴

Metadata

Variable	Description	unit
boy	ID
first_positive	Age at first spermatozoa-positive urine sample	years
entry	Age at start of study	years
exit	Age at end of study (eg. exit from study)	years
observations	Spermatozoa-positive urine samples
	+ = positive
	- = negative

who

Dimensions: Rows: 405440 Columns: 10